The Copine protein-derived peptide developed by HysensBio has shown therapeutic potentials in derma-related indications.

HB401 - Anti-aging
HB401 peptide has shown anti-aging effect by increasing collagen formation as well as filaggrin and involucrin in dermal fibroblast.

1. Filaggrin plays an important role in the skin's barrier function as it brings together structural proteins in the outermost skin cells to form tight bundles, flattening and strengthening the cells to create a strong barrier.
2. Involucrin is synthesized in the stratum spinosum and cross linked in the stratum granulosum by the transglutaminase enzyme that makes it highly stable. It provides structural support to the cell, thereby allowing the cells to resist from various invasions by micro-organisms.

HB501 - Vitiligo
Vitiligo is a long-term condition where pale white patches develop on the skin. It is mainly caused by the lack of melanin, which is the pigment in skin.

We have also developed a peptide which can treat vitiligo by increasing tyrosinase activity and melanin secretion in melanocyte.