NEXT-ATN: MRI-Based Alzheimer's Disease Diagnostics and Therapeutic Window Decision Tool

At NeuroXT Inc., we strive to build novel models to aid clinicians in early diagnostics of Neurodegenerative diseases (Specifically Alzheimer's Disease) and integrate Artificial Intelligence to predict optimal therapeutic windows for relevant drug implementations. NEXT-B, is our new and robust program that takes multimodal MR images to predict and calculate regional Amyloid PET (Positron Emission Tomography) biomarkers of the brain. The model also successfully predicts progression of beta-Amyloid accumulation, which serve as direct biomarkers for severity of neurodegeneration in Alzheimer's Disease. Ultimately, this model is aimed to ease the reliance on PET imaging for diagnosis of Alzheimer's Disease, and help detect early windows for Amyloid targeting therapeutics. We work hand-in-hand with numerous major radiology departments in local hosopitals and with international pharmaceutic companies for implementation of our model in real-world applications. Our prediction model reached sensitivity of 0.9. 

Software Flow

NEXT-ATN is not constrained to Internet/Server Connections. This is a standalone software built to work in local PC environments. As visualized above, this software takes in input NIfTI (.nii) MR images (T1 and DWI modalities) with relevant subject demographics to output regional Amyloid Uptake Ratios, Tau Retention Values and Atrophy Information (regions are segmented according to Deikan-Killiany Tourville Brain Atlas). All necessary output information can be visualized in our program and a summarized report with relevant values are also provided as outputs. All other files and data during preprocessing of images are also saved to output directories and a more detailed information regarding those file names will be provided in a user manual.

Software Information/Requirements

Below is a summarized list of information and prerequisite specifications for this software:

• Software Name: NEXT-ATN Local
• Version: 1.0.0
• Operating Environment:
• OS: Windows 10 or higher and WSL Version 2 or higher
• Linux: Ubuntu 20.04 or higher
• Server Connection via Network
• CPU: Intel Core i3 Processor equivalent or higher
• Memory: 8GB or higher
• GPU: NVIDIA GeForce RTX 3060 or higher recommended for faster processing speed
• Storage: 50GB of available space 
• Display: 1920x1080 px recommended for good visualization

For more information on software specfics, please leave inquiries and we will get back to you ASAP.