• Pomegranate extract
• MSM (Methyl SulfonylMethane)= Is made by oxidative metabolism of DMSO and it is source of organosulfur compounds (processed sulfur diet) containing sulfur which is mineral that is important element for human body to keep its functions and structure normally. According to various research reports so far, it has effect on the improvement of anti-inflammatory and function of joints so it has been recognized for its functionality as “MSN can be a help to the health of joints and cartilages” by MFDS.

◎ Estrogen
• It is female hormone involving ovulation and adjusts reproductive period
• Secretion: Majorly secreted in follicle and corpus luteum of ovary, placenta during pregnancy, adrenal gland testis etc.
• Function: It effects to the shape of woman’s body by revealing the secondary se xual character, increases endometrium, involves in growth of mymetrium, makes menstrual cycle (involves ovulation), changes mother’s body during pregnancy (adjusts thickness of uterine wall), makes growth of milk duct and promotes secretion
• It includes estrone (E1), estradiol (E2) and estriol (E3).
• Out of them, effect of E2 is the strongest and the weakest is E3.

◎ MSM (Methyl Sulfonyl Methane)
It is product of DMSO oxidative metabolism and it also is organic sulur compounds, which is source of sulfur that is important mineral for maintenance of normal function and structure of the human body. It has been reported through various research and study materials that MSM has effect on anti-inflammation and improvement of joint function. Therefore, MFDS (Ministry of food and drug safety) has recognized its functionality as “ It can be a help to the health of joint and cartilage”.

│ PRODUCT INFORMATION │

-Serotonin
• Most important neurotransmitter for the mechanism of hot flush
• Serotonin content in blood decreases caused by reduced estrogen secretion.

-Norepinephrine
• Its another name is noradrenaline.
• Hormone extracted with epinephrine from adrenal medulla
• Hot flush tales place when norepinephrine is inhibited by reduction of estrogen.

-Epinephrine
• It is hormone secreted in adrenal medulla and also called adrenaline.
• Epinephrine transfers stimulation to muscle by being secreted in sympathetic nerve.
• Increase of epinephrine increases heat loss and changes mechanism of heat loss to change body temperature, which finally makes hot flush.




-Estrone (E1)
• Shares 10 ~20% of the whole estrogen
• It is one of estrogen in human body produced in ovary and adrenal gland and in fat of human body before menopause
• More amount is discovered after menopause (because the fat material of human body produce them)
• It helps fat or weight of human body keeps healthy condition

-Estradiol (E2)
• Shares 10~20% of the whole estrogen
• It is hormone with the most important function and made by ovary before menopause
• It is the strongest one out of estrogen and biologically effects to estrogen receptor most actively
• It involves in many functions of woman’s body and disappears when ovarian follicle of the ovary is exhausted during menopause

-Estriol (E3)
• Occupies 60~80% of the whole estrogen
• The weakest hormone of the estrogen in human body
• It is produced in mass during pregnancy and small amount exist in woman’s body which is not pregnant

│ MSM(methyl-sulfonyl-methane) │

MSM which dissolves calcium phosphate assists to destroy harmful calcium precipitate which is the root cause of degenerative disease.

	Sulfur’s role for joint
	Sulfur is one of the components of protein which constitutes most of organizations of the body and it is essential component found mostly in protein which especially constitutes skin, blood vessel system, organs, hair and nail. As human body stores least amount of sulfur, cell which is functionally weak is produced in case sulfur that is required for making cell every day is not supplemented sufficiently.
	Effect of MSM on joint
	• Strengthens joint • Releases pain • Decreases edema • Improves blood circulation • Regenerates cartilage cell and improves flexibility

│ MSM/Joint health │

Despite the side effect of medicine (NSAIDs) for treatment of arthritis, there was no substitute for the people with joint disease. However, substitution medicine which is free from the side effect is now available thanks to clinical test and supply of refined MSM.

Stiffness of joint and motional function of joint started improvement considerably according to statistics after patient took MSM for 6 weeks and it was confirmed that pain and stiffness of joint as well as functions and motional function and even quality of life were improved after patient took MSM for 12 weeks.
The significance of the result is great as it is the result of clinical test for natural medicine which has no side effect of the medicine for joint treatment (NSAIDs).

* Ref. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. Debbi et al. BMC Complementary and Alternative Medicine 2001, 11:50

│ Reference material(1): Status of paper issued │

- Effects of Punica granatum (Pomegranate) Extracts on the Menopause Women
• J. Exp. Biomed. Sci. 2010, 16(1): 53~64

- The Effect of HP4060 on the Brain Neurotransmitter and Hot Flushes in the Female SD(Sparague-Dawley) Rat
• Medicinal Plants. J. Medicinal Food. 2002. 5(3): 153-158.

- Identification of Estrone in Pomegranate (Punica granatum) Extracts by Liquid Chromatography-Tandem Mass Spectrometry
• Food Sci. Biotechnol. 19(3): 000-000 (2010) DOI 10.1007/s10068-010-

- Analysis of estrogen in pomegranate extracts using LC/MS/MS
• J. Fd Hyg. Safety Vol. 25, No. 1, pp. 79~82 (2010)

- The Effect of Pomegranate Extracts on the Menopausal Syndromes
• J. Exp. Biomed. Sci. 15 (2009) 217–227

│ WOMAN WITH FOLLOWING SYMPTOMS NEEDS RED NO NO TIME │

- Hot flush
• Face is flushed and burns suddenly.

- Sweating • I sweat all of a sudden during ordinal life.
• Sweat much in the night.
• Much cold sweat.

- Heart inconvenience(circulatory system)
• Heart beats suddenly.
• Pulse jumps over.
• Heartbeat gets faster.
• Feels squeezing in the breast.

- Arthralgia, muscle pain, headache
• Have symptom similar to Rheuma.
• Pain in muscle or joint.
• Muscular strength gets weakened.
• Pain on the back, rear neck and head.

- Urination problem
• Have low back pain.
• Pee too often and feel remaining urine.
• Urine leaks unconsciously when I laugh or cough (urinary incontinence)
• Feel swollen.

- Bad-tempered(Nervous system)
• Feel acute on nerves.
• Lose patience in human relationship.
• Feel having aggressive personality.

- Anxiety
• Feel panic condition.
• Feel uncomfortable and get nervous.
• Life is not satisfactory.
• Feel tension usually.

-Insomnia
• Difficult to sleep usually.
• Can’t take sound sleep.
• Sleeping hour gets reduced.

-Depressive disorder
• Feelings droop.
• Feel sad.
• Tear drops easily.
• Want to be alone due to social phobia.

- Physical and psychological fatigue
• Daily life performance gets weakened generally.
• Working is not as good as working in the past.
• Memory power and concentration get weakened and amnesia is getting serious.
• Get tired frequently and easily exhausted.
• Much gas in the stomach or feel bloated.
• Endurance is getting weakened.
• Feel that vitality is not enough.

- Skin problem and alopecia
• Skin gets dry and dark.
• Face gets downy hair and fine wrinkles.
• Skin gets tough and loses elasticity.
• Hairs get thinner and lots of hair fall out suddenly (alopecia)

- Se xual problem
• Vagi nal secretion decreases so feel dry.
• Feel se xual pain when make love as vagi nal mucus is not secreted.
• Number of times for making love get reduced and avoid se xual intercourse.
• Cannot feel se xual satisfaction.

│ DOSE FOR RED NONO TIME AND RESPONSE AFTER INTAKE │

1. Dose(600mg)
1) Age 35 ~ 45 or under : 4 ~ 6 tablets a day
2) Age 45 ~ 55 or under : 6 ~ 8 tablets a day
3) Age 55 or older : 8 tablets a day


2. Symptoms after intake

1) 1~15 days after intake
① Feel tingling irritation on the teat of breast and sometimes feel numb or get sensitive.
② Breast expands and feel as if it has been bigger.
③ Vagi nal secretion (lubricant)increases.
④ Have headache or feel dizzy and somewhat feel like throwing up.
⑤ More tired than usual time, have more sleeping hours and sound sleep.
⑥ Color of urine changes and number of urination time and amount increases.
⑦ Skin trouble (rash etc.) appears and feel itching on the skin.

2) 15~30 days after intake
① Constipation disappears and get regular motions.
② Skin change to fine condition so make-up has effect.
③ Parts with pain (especially, joints, low back etc.) may be more painful temporarily.
④ Amount menstruation increases menstruation blood changes to scarlet color and unique unpleasant odor disappears.
⑤ Women who had menopause within 1~3 years before may have menstruation again.

This is good phenomenon for women who experiences reduced menstrual amount or menopause caused by reduction of estrogen (female hormone).

As, endocrine metabolism and menstrual functions are getting better, color of menstrual blood changes to fine color, menstrual amount increases and coagulated blood breaks out. Thus, response as described as above are reactions that keep light and pleasant physical condition.

3) General symptoms
① Vagi nal secretion increases and feel like being closely packed in vagi na.
② Nipple changes to light dark and feel expansion and pain of breast.
③ Heart is stuffy and beats and the symptom is similar to morning sickness during pregnancy.
④ Lower belly gets stiff before menstruation and menstrual amount increases.
⑤ Menstruation comes again after menopause.
⑥ Changes in skin (itching, hives, rash, furuncle etc.).
⑦ Hyperemia and eye discharge take place in the eyes and amount of tear increases.
⑧ Body gets tired and sleeps more with slight fever.
⑨ Cramp takes place on the foot or face and legs are swollen.
⑩ Causes joint and articulation to be painful.


※ The symptoms as describes above are phenomenon take place temporarily to persons who have sensitive stomach and bowel or whose physical condition is in a state of tension or who have serious hot flush, cold sweat, insomnia and depressive disorder because of reduced secretion of estrogen (female hormone). If you experience those symptoms, you may feel relieved as it is a process in which estrogen (female hormone)is increases.

※ Though we recommend continuous intake of the product as the symptoms appear to persons who take the product for the first time and it is phenomenon that can be taken place by increase of estrogen (female hormone), if it is difficult to take inevitably, reduce the quantity of intake or stop taking for the time being and try intake again.

※ Above mentioned symptoms take place more frequently to persons especially persons who had weak endocrine function or metabolism or persons who experience difficulties with hot flush, cold sweat, insomnia and depressive disorder because of drastic reduction of estrogen (female hormone).

※ If you are inconvenient to have normal life due to above symptoms, reduce the quantity of intake by half and take them. As short amount of female hormone can vary individually regardless age, it is important to take as exact amount as you need.

※ While you are taking the product, select amount which makes your body condition optimized and keep the amount. And you will keep healthy life as woman with the best beauty and attractiveness.