Cytopatch Instrument

Cytopatch Instrument


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Keyword
Category
Education Supplies

S & T Corp.

Membership
BIZ
Country / Year Established
South Korea South Korea /
Business type
Distributor
Verified Certificate

13

DUNS

Product name Cytopatch Instrument Certification -
Category Education Supplies Ingredients -
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Product Information

Software integrates up to 20 modules

Patch clamp: "Gold standard" for Ion Channel Screening

Quality criteria for accurate shole-cell recordings:

  • high seal resistance (Rseal>1GOhm)
    Rseal = 2.7GOhm(n=76, Kv1.5)
  • high and stable membrane resistance (Rmem>500MOhm)
    94% stable whole-cell after gigaseal (Kv1.5), continuously monitored
  • low access resistance (Ra<10MOhm
    Ra=9.92MOhm(n=47, HEK hERG cells)
  • stable whole-cell configuration for at least 15 min

CytoPatchTM Chip

Cytocentering channel to position a single cell

  • one cell is positioned on top of the patch pipette by applying an accurate pressure controle

The CytoPatchTM Pipette resembles a "real" patch pipette:

  • glass surface for real gigaseals
  • shape and diameter (ca. 2μm)
  • no contamination of the tip of CytoPatchTM pipette: positive pressure until sealing
  • Rpip ca. 8MOhm (Ver.1) or ca. 4MOhm (Ver.2)

Advantage :

  • high data quality due to stable gigaseals
  • robust whole-cell recordings → high success rates and high through-put

Fig2. Micromachined patch-clapm chip with embedded microfluidie channels. A) Schematic cross section. B) Cross section of the contact area obtained by focused ion beam (FIB) and SEM technique. C) SEM image of the pipette structure. Fig.3 Contacting of cell and chip. The chip is sealed in a silicone rubber packaging that contains micro channels. These are contacted and filled via penetracting cannulaes, that are also used for cell and compound injection into the transport channel, pressure application for cell positioning and electrical contacting.

CytoPatchTM Rapid Perfusion System

  • Quality and flexibility: rapid perfusion system
  • Continuous perfusion with extra-cellular solution
  • Continous perfusion with compound, fast and precisely triggered
  • Continuous pre-incubation with compound (e.g. antogonist) and subsequent second application (e.g. agonist)

CytoPatchTM Rrapid Perfusion System

Kinetics of hERG channel blockers Fluvoxamine and Astemizole


Application of 10μM Fluvoxamine and 20nM Astemizole

 

B2B Trade

Price (FOB) Negotiable transportation -
MOQ Negotiable Leadtime Negotiable
Payment Options Negotiable Shipping time Negotiable

S & T Corp.

Country / Year Established
South Korea South Korea /
Membership
BIZ
Business type
Distributor

13

DUNS

President
Sangbong Park
Address
3F, 314, Jahamun-Ro, Jongno-Gu, Seoul, South Korea. 03017
Product Category
Education Supplies,Machinery & Parts
No. of Total Employees
1-50
Company introduction

CYTOCENTRICS - Your Competent Equipment Manufacturer for Automated Patch Clamp and Reliable Partner in Ion Channel Screening Services.
We provide complete solutions in the field of automated patch clamp and help you to achieve your goals efficiently. Our instruments are designed to simplify the difficult patch clamp process, resulting in significant time and cost reductions for our customers.

Because the characterization of ion channels is highly dependent on the electrophysiological properties of the specific channel of interest, as part of our service, we will consult with you regarding assay design and then offer you a tailor-made solution.

Our current expertise is based upon:
- Development and sale of the CytoPatch Instrument, an automated patch clamp platform
- Ion channel screening service: Safety- and Efficacy Screening
- Execution of GLP studies
- Ion channel assay development
- Development of electrophysiologically validated cell lines
- Sale of ready-to-use kits with quality-assured cells and buffers as turnkey solution
- Optimization of cell lines and buffers

Main Markets

China China

Japan Japan

South Korea South Korea

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