| NEUBO HT008-1 SAMPLE SPECIFICATIONS

-. Specifications
Invigorant foodstuff of oriental medicine for protection of brain cell

-NEUBO HT008-1

-. About Product / NEUBO HT008-1  for cognitive improving

Developing background

1. Product developed under the support of Plant Diversity Research Center in the Ministry of Science & Technology, Korea.
2. Finally succeeded in developing new substance HT008-1 which is most effective in treatment of stroke, dementia, after searching for 190-odd herb medicinal stuffs recorded in Dong UiBo Gamand other oriental medicinal books.
3. Commercialization of product -Reinforcing invigorant ingredient which prevents from growing old and supplying energy, to the new substance HT008-1.

Scientific effect

American J. Chinese Medi. 36(2), 2008, 287-299, Pharn. Biochem. Behav, 90(2008) 517-524 Korean J. herbology22(4) , 2007, 51-58

1. It has proved that the product controlled destruction of brain cell and protected sensory nerve in animal model which have occlusion of artery in cerebrum/midbrain.
2. It has proved that the product controlled destruction of hippocampus' neuron and protected sensory function in animal model which have 4-vessel occlusion.
3. It was clinically verified that learning ability and power of memory for normal person have been improved (conducted in oriental medical center, Kyung heeuniversity).

Recommend to

1. Learning and cognitive abilities improvement
2. Improving physical functions In case of clinical history of stroke, dementia in one's family
3. Feeling absent-minded, lack of concentration
4. Feeling tired and lack of energy frequently
5. Students preparing for examination
6. Mental labor intensive person
7. Recovery from chronic fatigue

Features

1. Outstanding oriental medicinal product developed by research team led by Prof. HocheolKim, college of east medicine, Kyung heeuniversity, after 5 years of their researching process supported by Plant Diversity Research Center in the Ministry of Science & Technology-Reliable effect owing to long-term of research and clinical trials.
2. Definite efficacy without any side effect due mainly to the quality of medicinal stuffs and optimum mixture.
3. Standardization of Raw-materials to the final are conducted by specialists.
4. High Korean Ginseng extract content
5. Under KFDA –claim certification

-. About Product / NEUBO HT008-1

- Description

HT008-1, a multiherbmixture composed of four herbs :
Acantopanaxsenticosus:
Angelica sinensis:
Scutellaria baicalensis
Panax Ginseng

'HT008-1' clinically proven to improve memory
and cognitive function and also have demonstrated safety with no known adverse effects.

- Neuroprotectiveeffect

Neuroprotectiveeffect of HT008-1

Hippocampus cell death was decreased in dementia model at HT008-1 consumption group

Infarction inhibitory effect of HT008-1

Infarction was decreased in stroke model at HT008-1 consumption group

-. Clinical test of NEUBO(HT008-1 BrainCare) on Cognitive improving effect

Kyung HeeUniversity Medical Center have conducted Clinical trial of the efficacy of ‘HT008-1’ on the neuropsychological functioning and quality of life (QoL) in cognitively intact adult. 190 male and female volunteers who reported no history of dementia or significant neurocognitiveimpairments were administrated for 8-weeks, randomized, double-blind, fixed-dose, placebo-controlled.

- Cognitive function

WMS-III subtests, the HT008-1 group demonstrated significant improvement in Logicalmemory I (p=0.006), Logical memory II (p=0.008), Verbal paired associates I (p=0.001), and Auditory recognition delayed (p=0.075),

- Quality of Life

The participants who received HT008-1 for 8 weeks exhibited significant improvement in
General Health compared with the placebo group in the lower third group, there were significant differences in General health (p=0.043), Domain I (physical health; p=0.022), II (psychological health; p=0.003), and III (social relationship; p=0.035) of WHOQoL-Bref

- Safety

No serious adverse events were reported during the Study.