Novel small molecules for treating NASH

Novel small molecules for treating NASH

Novel candidates for NASH: Novel thiourea derivatives bind to RORα protein which leads to suppression of lipid accumulation in hepatocytes


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Place of Origin
South Korea
Payment Terms
Others
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Available
Shipping / Lead Time
Negotiable / Negotiable
Keyword
nash, metabolic disease, small molecule, rorα activator
Category
Medicines

Seoul National University R&DB Foundation

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VIP
Country / Year Established
South Korea South Korea / 2003
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Others
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Product name Novel small molecules for treating NASH Certification -
Category Medicines Material -
Keyword nash , metabolic disease , small molecule , rorα activator Unit Size -
Brand name - Unit Weigh -
origin South Korea Stock 100000
Supply type Available HS code -

Product Information

Unmet Needs
• Nonalcoholic steatohepatitis (NASH) is a liver disease that is characterized by the accumulation of fat in the liver, inflammation, and liver cell damage with multiple underlying factors contributing to its pathogenesis such as obesity, insulin resistance, dyslipidemia, and gut dysbiosis
• There are currently no FDA-approved drugs for the treatment of NASH, and clinical management involves lifestyle modifications such as weight loss, dietary changes, and exercise

Technology Overview

• Exacerbation of non-alcoholic steatohepatitis (NASH) is associated with mitochondrial dysfunction and a homeostatic imbalance

• Retinoic acid receptor-related orphan receptor α (RORα) enhances oxygen consumption rate and expression of genes associated with mitochondrial quality control

• Novel thiourea derivatives directly bind to RORα protein and increase transcriptional activity which leads to suppression of lipid accumulation in hepatocytes

 

Patent Pending

Country

Application number

Filing date

(yyyy.mm.dd)

Status

PCT

PCT-KR2022-017924

2022.11.15

Unpublished

 

Paper

Lee, Mi-Ock, et al. “RORα suppresses interleukin-6-mediated hepatic acute phase response”. Sci Rep. 2019 Aug 13;9(1):11798.

 

Park, Hyeung-Geun, et al. “Enantioselective Synthesis of Chiral α‐Alkylthiomalonates via a Phase‐Transfer‐Catalyzed α‐Sulfenylation of α‐Alkylmalonates”. Asian J. Org. Chem. 2019, 8, 1732–1739.

 

Product Info Attached File

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Seoul National University R&DB Foundation

Country / Year Established
South Korea South Korea / 2003
Membership
VIP
Business type
Others

2

DUNS

President
Jaeyoung KIM
Address
Kwanak-ro 1, Gwanak-gu, Seoul, Korea
Product Category
Other Analyzers
Year Established
2003
No. of Total Employees
101-500
Company introduction

 

Main Markets

South Korea South Korea

Main Product

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