A very small amount of the tissue regenerating substance, PDRN, is found in placenta and semen of salmon. However, due to ethical problems and difficulties in medicinal product production, PDRN in placenta was not used but PDRN in salmon, a fish, was used as an alternative to the placenta. The DNA substance extracted from salmon matches a considerable amount of DNA sequences of the human body so when it is applied to human skin, its effect is excellent, so in Europe, it is professionally used in treating burns and damaged cartilage and bone.. PDRN, made up of a specific size DNA polymer extracted from salmon, is a material of the cells that make up the skin [DNA], which helps bioactive synthesis in the skin stem cell stage. It has excellent effects on skin regeneration and helps to accelerate DNA synthesis when penetrated into skin tissue. Its effect can be felt more intensely the more troubled the skin is since it quickly promotes skin regeneration by penetrating directly into the damaged tissues and has an antioxidant effect that activates cell regeneration,. It is also characterized by activating the production of various proteins and promoting the differentiation of various cells. Currently, PDRN is used to treat arthritis as well as skin regeneration. It is mainly used for the treatment of degenerative arthritis and also affects musculoskeletal diseases of parts such as shoulder, knee and back, plantar fasciitis, elbow and wrist pain.