Apolipoprotein E (ApoE) Genotyping Kit
Negotiable Min Order Quantity Unit
- Required Quantity
-
- Place of Origin
- South Korea
- Payment Terms
- Negotiable
- Production method
- Negotiable
- Shipping / Lead Time
- Negotiable / Negotiable
- Category
- Other Chemicals , Chemical Reagents & Products
SOLGENT CO., LTD.
- Verified Certificate
-
16
Product name | Apolipoprotein E (ApoE) Genotyping Kit | Certification | - |
---|---|---|---|
Category |
Other Chemicals
Chemical Reagents & Products |
Ingredients | - |
Keyword | molecular diagnostic , realtime pcr , apolipoprotein e , alzheimer | Unit Size | - |
Brand name | - | Unit Weigh | - |
origin | South Korea | Stock | - |
Supply type | - | HS code | - |
Product Information
Real-Time PCR (or Multiplex allele-specific PCR) based assay system for the genotyping
of the ApoE gene SNP related to alzheimer’s disease
Genetic information
Apolipoprotein E (ApoE) consists of three isoforms: E2, E3 and E4. These three isoforms make six genotypes, (homozygous genotypes: E2/E2, E3/E3 E4/E4 and heterozygous genotypes: E2/E3, E2/E4, E3/E4). Isoform E2 is usually known as a protective isoform whereas isoform E4 is generally responsible for diseases. The predominant abnormalities are due to a single nucleotide polymorphism (SNP) of codon 112 (Cys/Arg) and codon 158 (Arg/Cys). The polymorphism has functional effects on the lipoprotein metabolism. ApoE is the primary ligand for two receptors, LDL receptors found in the liver and other tissues and ApoE specific receptors found in the liver. The co-ordinate interaction of these lipoprotein
complexes with their receptors forms the basis for the metabolic regulation of cholesterol. ApoE has been found to be associated with elevated cholesterol levels or lipid derangements that lead to various clinical problems like coronary heart diseases, strokes, periphery artery diseases, and diabetes mellitus. In addition to the genotype-phenotype associations with the cardiovascular disease, the alleles and isoforms of ApoE have been related to dementias, most commonly Alzheimer’s disease. Determining the genotype of ApoE is thus considered to be an important test for patients with the disease, as well as a precautionary test for healthy people.
Production Specification
|
DiaPlexQ™ ApoE Genotyping Kit |
DiaPlexC™ Apolipoprotein E (ApoE) Genotyping Kit |
Detection target |
ApoE genotype (Mutation T112C and T158C of ApoE gene) E2/E2, E3/E3, E4/E4, E2/E3, E2/E4, E3/E4 |
|
Detection technology |
Real-Time PCR |
Conventional (End-point) Multiplex PCR |
Specimen type |
Blood |
|
Compatible instruments*
|
ABI 7500 / 7500 Fast Real-Time PCR System (Applied Biosystems) CFX96™ Real-Time PCR System (Bio-Rad)
|
ABI Veriti thermal Cycler (Applied Biosystems) recommended
|
PCR running time |
~ 1 hr 30 min |
~ 1 hr 30 min |
* Please inquire us for compatible instrument information before use.
Product Features
- HotStart PCR system : Ultra high specific and sensitive result
- UDG system : No carryover contamination (DiaPlexQ™)
- Multiplex PCR : Multiple targets in a single reaction
- Reliable system : Automatic Internal control (DiaPlexC™)
- Positive control included
- Easy-to-use master mix
- CE certification
Reference
1. Lepara O, Valjevac A, Alajbegovic A, Zaciragic A, Nakas-Icindic E (August 2009). Decreased serum lipids in patients with probable Alzheimer’s disease”. Bosn J Basic Med Sci 9 (3): 215-20.
2. Golomb BA, Evans MA (2008). “Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism”. Am J Cardiovasc Drugs 8 (6): 373-418
Result
& Data interpretation
Ordering Information
Technology |
Cat. No. |
Product |
Contents |
Real-Time PCR |
SQH01-K020
(20 reaction) |
DiaPlexQ™ ApoE Genotyping Kit |
2X Multiplex Real-Time PCR Smart mix (ApoE) Primer & Probe Mixture (ApoE 112) Primer & Probe Mixture (ApoE 158) T/T type Control DNA (ApoE 112) T/C type Control DNA (ApoE 112) C/C type Control DNA (ApoE 112) T/T type Control DNA (ApoE 158) T/C type Control DNA (ApoE 158) C/C type Control DNA (ApoE 158) Nuclease free Water
|
SQH01-K100 (100 reaction) |
|||
Conventional (End-point) PCR
|
SHG01-K020 (20 reaction) |
DiaPlexC™ Apolipoprotein E (ApoE) Genotyping Kit
|
2X Multiplex PCR Smart mix (ApoE) Primer Mixture (ApoE) Standard Marker (ApoE) Control Template (ApoE) Nuclease free Water
|
SHG01-K100(100 reaction)
|
B2B Trade
Price (FOB) | Negotiable | transportation | - |
---|---|---|---|
MOQ | Negotiable | Leadtime | Negotiable |
Payment Options | Negotiable | Shipping time | Negotiable |
- President
- MYEONG, HYEON-KOON
- Address
- 32, 3F Techno6ro Yuseong-gu Daejeon
- Product Category
- Other Chemicals
- Year Established
- 2000
- No. of Total Employees
- 51-100
- Company introduction
-
SolGent InC, established in 2000, is a technuical market leader in the field of molecular biology. Based on the research ecperiences in KAIST(Korea Advanced Institute of Science and Technology), we are launching the leading products which meet the unremitting needs of life science. Our major products are PCR related thermostable ploymerases, DNA ligase, RNA plymerases, Reverse Tranx-x-scriptase, and DNA ligase RNA polymerases, Reverse Transcriptase, of genetic analysis, we are also providing the sequencing and genotyping services. The products and services are so competitive in the quality as well as the price. Especially, we are proud of the recently developed novel products, SEQrooge and H-Taq. You can find them here and enjoy their performances. Thank you
- Main Markets
-
Canada
China
France
Germany
Philippines
- Main Product
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