Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-0101

Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-0101


Negotiable Min Order Quantity Unit

Required Quantity
Place of Origin
U.S.A
Payment Terms
Negotiable
Production method
Negotiable
Shipping / Lead Time
Negotiable / Negotiable
Keyword
antibody, adc
Category
Medical Devices

Creative Biolabs

Membership
BIZ
Country / Year Established
U.S.A U.S.A / 2005
Business type
Manufacturer
Verified Certificate

8

DUNS

Product name Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-0101 Certification -
Category Medical Devices Ingredients -
Keyword antibody , adc Unit Size -
Brand name - Unit Weigh -
origin U.S.A Stock -
Supply type - HS code -

Product Information

 

 

 

This ADC product is comprised of an anti-TACSTD2 monoclonal antibody  (hRS7) conjugated via a CL2A linker to SN-38. The SN-38 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, SN-38 binds to DNA, causes DNA damage. Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood. SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1 Binds to DNA, causes DNA damage.

 

 

 

B2B Trade

Price (FOB) Negotiable transportation -
MOQ Negotiable Leadtime Negotiable
Payment Options Negotiable Shipping time Negotiable

Creative Biolabs

Country / Year Established
U.S.A U.S.A / 2005
Membership
BIZ
Business type
Manufacturer

8

DUNS

President
Mr
Address
SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA
Product Category
Other Pharmaceutical Chemicals
Year Established
2005
Company introduction

 

Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world.
 
Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price. Our products range from antibody / peptide libraries, Biosimilar cell lines, Chimeric antigen receptor (CAR) products, antibody-drug conjugates (ADCs) to engineered antibodies such as therapeutic antibodies, nanobodies, bispecific antibodies and intrabodies. We also provide professional custom antibody discovery and engineering services, featuring phage display library construction, antibody humanization, chimerization, engineered antibody production (Fab, scFc, tribody, bispecific antibody, nanobody, minibody, etc.), antibody labeling, hybridoma/stable cell line development, membrane protein production and cGMP-manufacturing which enable larger scale antibody production for development of animal-based assays and clinical trials.

 

Main Product

Related Products

Other buyers also search

Membership Grade

BUYER

Biz Pro VIP

SELLER

Biz Pro VIP
팝업닫기
Live Chat A new message arrives
from a business partner.

No Data

  • There is no data to load
  • Check out the My TK > My Inquiries list.
  • After agreeing to the use of the Live Chat service, the list is printed only when there is at least one history of receiving or sending a Live Chat request.

If you have not yet agreed to use the Live Chat service,

You can use the Live Chat freely after agreeing to the use of the Live Chat service.

View more
View more