Adipotide

Adipotide


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Place of Origin
China
Payment Terms
Negotiable
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Negotiable
Shipping / Lead Time
Negotiable / Negotiable
Keyword
adipotide
Category
Other Pharmaceutical Chemicals

Aierry Co.,ltd.

Membership
BIZ
Country / Year Established
China China / 2016
Business type
Manufacturer
Verified Certificate

8

Product name Adipotide Certification -
Category Other Pharmaceutical Chemicals Ingredients -
Keyword adipotide Unit Size -
Brand name - Unit Weigh -
origin China Stock -
Supply type - HS code -

Product Information

 

AIAP0013 Adipotide
Aditpotide is an experimental weight loss peptidomimetic with the amino acid sequence CKGGRAKDC-GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to
fight obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide.
The peptide called Adipotide has been developed by U.S. researchers in the fight against the obesity . This experimental treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and waist circumference.

Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells thereby
causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death (apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production of proteins that effect the apoptotic process.

Molecular studies have revealed that Adipotide possess a unique stereo-chemical (3D) conformation which enables
it to bind to only two receptors in the body: ANXA-2 and prohibitin. These receptors are located on the surface of the
endothelium (innermost wall lining) of the blood vessels supplying the white adipocytes, and as such, these receptors confer tissue specificity to adipotide. Formation of white adipocytes only occurs when the extent of energy consumption far exceeds energy utilization, and its (white adipocytes) formation and accumulation in the subcutaneous layer serves as a hallmark of obesity.

Obesity

Pathological studies have shown that obesity serves a risk factor for a myriad of diseases such as cancer, hypertension, endocrine disorders (such as diabetes mellitus, hyperlipidemias and metabolic syndrome), cardiovascular disease (such as stroke and myocardial infarctions) and degenerative diseases (such as osteoarthritis). Moreover, aberrant accumulation of white adipocytes predisposes the affected individual to lipoma and lipomatosis. It is well known that abdominal adiposity is mainly caused by white adipocytes, and this form of adiposity is the most lipolytically active, thus requiring a steady blood supply. Any interference with the blood supply causes it to activate the apoptotic process.

Selected Studies
Studies done by Mikhail G Kolonin et al have shown that adipotide has the capabilities of inducing apoptosis of the vascular bed of the white adipocytes in mice, and this resulted in the normalization of metabolic processes.

A related study conducted by Kirstin F. Barnhart et al on monkeys have shown that adipotide induced apoptosis of the vascular bed of the white adipocytes with a resultant weight loss and normalization of insulin function. These studies show that adipotide does cause weight loss by inducing selective apoptosis.

Adipotide and Fat Loss / Weight Loss
Adipotide is an experimental treatment that prevents the blood supply to fat cells. This has helped obese monkeys to lose on average 11% of their body weight in four weeks, perhaps opening the way for therapy in humans, according to a recent research study. The study, published in the journal Science Translational Medicine , shows that body mass index and waist circumference of the rhesus monkeys were reduced.

 

B2B Trade

Price (FOB) Negotiable transportation -
MOQ Negotiable Leadtime Negotiable
Payment Options Negotiable Shipping time Negotiable

Aierry Co.,ltd.

Country / Year Established
China China / 2016
Membership
BIZ
Business type
Manufacturer

8

President
Peter Liang
Address
A201, No.1 Qianwan 1st road, Qianhai economic district, Shenzhen.
Product Category
Other Pharmaceutical Chemicals
Year Established
2016
No. of Total Employees
1-50
Company introduction

 

Aierry Co.,ltd is a professional supplier of peptide related products,
peptide costom R&D and costom manufacturing, our products
include generic peptide, bioactive peptide and cosmetic peptide.
Aierry is located in Shenzhen Qianhai Economic district. our peptides
are exported to North America, West Europe, South America,
East Europe and Southeast Asia etc. We insist on"Quality first,
Innovation, Credibility and Win-win", providingquality peptides
to our customers worldwide.

Vison: to be the leading provider of peptide products  
Mission:  provide high quality peptides  
Core Value:  Quality, Innovation, Credibility, Win-win
Main Markets

Argentina Argentina

Canada Canada

Egypt Egypt

Iran Iran

Iraq Iraq

Israel Israel

Jordan Jordan

Saudi Arabia Saudi Arabia

U.A.E. U.A.E.

U.S.A U.S.A

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