Knockdown Services
Negotiable Min Order Quantity Unit
- Required Quantity
-
- Place of Origin
- U.S.A
- Brand name
- Creative Animodel
- Payment Terms
- Negotiable
- Production method
- Negotiable
- Shipping / Lead Time
- Negotiable / Negotiable
- Category
- Pharmaceutical Intermediates
Creative Animodel
- Verified Certificate
-
10
| Product name | Knockdown Services | Certification | - |
|---|---|---|---|
| Category | Pharmaceutical Intermediates | Ingredients | - |
| Keyword | rnai gene knockdown , knockdown services , gene knockdown | Unit Size | - |
| Brand name | Creative Animodel | Unit Weigh | - |
| origin | U.S.A | Stock | - |
| Supply type | - | HS code | - |
Product Information
RNA interference has become a widely used approach to perform gene knockdown experiments in cell cultures and more recently transgenic animals. It has developed into a routine method to assess gene function in a fast and easy manner. Since 2008, Creative Animodel's scientists have generated more than 200 RNAi models for innovative biomedical researchers. These RNAi models allow researchers to induce and reverse gene knockdown in transgenic mice at selected time points in vivo.
We have developed RNAi-mediated gene knockdown mice by:
Silencing lentiviral vectors and adenoviral vectors
Transgenic mice can be generated rapidly by transduction of early embryos with lentiviral silencing vectors and adenoviral vectors, resulting in mice with down regulated target genes. These methodologies offer the possibility of large-scale generation of knockdown transgenic mice for functional genomic studies and enable the production of transgenic mice in 7 weeks.Cre/loxP system as an activate RNAi in a time- and tissue-dependent mannerSingle-copy RNAi constructs are placed into the Rosa26 locus of ES cells by recombinase-mediated cassette exchange and transmitted through the germline of chimaeric mice. The site-specific insertion of single-copy shRNA vectors allows the expedite and reproducible production of knockdown mice and provides an easy and fast approach to assess gene function in vivo.
B2B Trade
| Price (FOB) | Negotiable | transportation | - |
|---|---|---|---|
| MOQ | Negotiable | Leadtime | Negotiable |
| Payment Options | Negotiable | Shipping time | Negotiable |
- President
- Mr.Zhang
- Year Established
- 2005
- Company introduction
-
Creative Animodel totally understands that it is a challenging and long-time process to develop novel therapies especially anticancer regimens. As an experienced bioscience CRO, we would like to help you accelerate the process through our preclinical services including PD, PK, toxicology services and the establishment of tumor-bearing animal models, the supply of tumor cell lines and tissues, and the support of tumor related biotechniques.
Our highly experienced preclinical team has performed a huge number of PD, PK, and toxicology experiments to evaluate novel compounds. According to our detailed protocol, specific aspects of drug property and its mechanism of action are fully understood. During researches, the study results will be sent to clients in a timely and cost-effective manner. If necessary, clients can also work with our PD, PK or toxicology team to design the most appropriate protocol and monitor the whole experimental process.
In the past years, Creative Animodel has collected more than 80 cases of human tumors. At present, 30 cases are growing as subcutaneous xenografts in nude mice, and others were retained as nitrogen frozen samples. Tumors types comprise: stomach, lung, liver, pancreas, kidney, bladder, skin, breast, brain, colon, prostate, sarcomas (bone), uterus, ovary and hematological models. Also, we have a full range of human tumor cell lines that have been validated in our in vivo efficacy studies or reported in literature. According to the requirements from clients and our experience, Creative Animodel can offer subcutaneous, orthotopic, metastatic, transgenic and chemoinduced models using these tumor samples and cell lines.
Additionally, Creative Animodel provides powerful tumor-related biotechniques support for clients. Our services focus on in vitro and in vivo preclinical studies as well as toxicological, pathological, and toxicokinetics researches.
Creative Animodel has constructed systematic data and experience in pharmacology or oncology services. If you are interested in our laboratory, please contact us. Our research scientists will work closely with you to develop detailed study protocols to meet your goals.
- Main Markets
-
Australia
Canada
Singapore
South Korea
U.S.A
- Main Product
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