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AVANTE Injection

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KBNP Inc.

Country / Year Established: South Korea /

Business type: Others

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DUNS

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Product Information

Description

AVANTE injection contains the sodium salt of ceftiofur which is a broad spectrum antibiotic effective against gram-positive and gram-negative bacteria including β-lactamase producing microorganisms. Like other cephalosporins, ceftiofur is bactericidal by inhibition of cell wall synthesis.

In particular, AVANTE injection is often used for new born piglet colibacillosis, pleuropneumonia, pasteurella-pneumonia of weaning pig, calf pneumonia and shipping fever caused by pasteurella.

Characteristics

More effective
AVANTE is a, bactericidal antibiotics, killing target pathogens. AVANTE is highly effective in treating respiratory diseases caused by the major pneumonia pathogens in pig and cattle.
More rapid
When administered intramuscularly, plasma concentrations reachto 100 times higher than minimum inhibitory concentration(Mlc) for target respiratory pathogens within one hour.
More tolerable
AVANTE is a safe product that doesn't irritate the injection site.
More convenient
AVNATE is easily reconstituted without removing top of the cap and highly syringeable.

Bioavailability

Ceftiofur sodium is quickly absorbed within an hour after intramuscularly injection, reaches to a high initial peak and maintains for maximum 35 hours by therapeutic levers

Antibacterial activity of AVANTE injection

MICs for main pathogens isolated from pigs

Organism	No.tested	MIC	MIC₉₀	Sensitivity (%)
A. pleuropneumonia	83	≤0.03~0.06	≤0.03	98.7%
P. multocida	74	≤0.03~0.06	≤0.03	99.2%
S. suis	94	≤0.03~1.0	0.25	99.6%
S. cholerasuis	50	1.0~2.0	1.0	97.8%
H. parasuis	76	0.0039~0.25	0.06	99.9%

MICs for main pathogens isolated from cattle

Organism	Antibiotics	MIC₉₀	Sensitivity (%)
P. hemolitica	Ceftiofur Spectinomycin Tilmicosin Ampicilin Tetracycline Sulfamethazine	<=0.03 64.0 8.0 82.0 32.0 512.0	100.0 83.5 69.1 60.5 57.0 46.2
P. multocida	Ceftiofur Ampicilin Tetracycline Tilmicosin	<=0.03 8.0 16.0 8.0	100.0 88.1 71.1 58.0
H. somnus	Ceftiofur Tetracycline Tilmicosin Ampicilin	<=0.03 1.0 4.0 1.0	100.0 98.2 90.4 90.1

Percentage of isolates sensitive to antibiotic

The results of this survey are that ceftiofur demonstrated the highest levels of sensitivity to commonly observed swine respiratorv infections

Case report of Swine application

Efficacy of ceftiofur in suckling piglet (14 days old)

	Ceftiofur	Control	Difference
Mortality rate(%)	7.5	11.0	-31.8%
Average daily gain (Birth to weaning, g)	215	204	+5.4%
Under weight weaning pig (<3.6kg, %)	12.4	14.8	-16.2%

Efficacy for Actinobacillus pleuropneumonia(APP) in growin pig

		Lung lesion(%)	No.of symptom(%)
Ceftiofur(25pigs)	3mg/kg	10.0	11 (44%)
Control(25pigs)	Saline	29.1	20 (80%)

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KBNP Inc.

Minisite Heart

Country / Year Established: South Korea /

Business type: Others

TRADE TOWER

DUNS

President: SONG, KI YEON

Address: 254-18 Dugok-ri, Sinam-myeon, Yesan-gun, Chungcheongnam-do, 340-861 KOREA

Product Category: Medical Devices,Veterinary Instrument

No. of Total Employees: 51-100

Company introduction: The most famous player in animal health industry in Korea, KBNP is a Korean manufacturer of animal health products including biologicals, injectables, water solubles, oral solutions, premixes, aquaculture and disinfectants for intensive livestock and poultry production and companion animals.
Founded in 1989, KBNP took over the animal vaccine business unit from Bayer Korea in December, 2001 and completed the latest model of biological production facilities complied to Korean Good Manufacturing Pracitce.

The company has grown into successful national player in biologicals and biosecurity. It produces highly immunogenic vaccine (Himmvac) and high quality innovative animal healty and hygiene products which are very famous and competitive in national market.
KBNP has highly profiled personnel resources both in marketing and sales department. It provides livestock farms throughout the country with fast and accurate analysis information. KBNP is doing its best to become a company that is trusted by the customers and provides reliable products.

In order to centralizing investment on the vaccine industry, which can be called the core of animal health business, the relocation of the vaccine facilities in Yesan acquired KVGMP.
For the costomers, company and shareholders to get along and grow together, KBNP put its company philosophy basis of basics and principles. KBNP will be also volunteered to be environment-friendly company.